mots-c: the mitochondrial-derived peptide for metabolic resilience
What Is MOTS-c?
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA type-c) is a peptide encoded in mitochondrial DNA, which sets it apart from most other peptides that are encoded in nuclear DNA.
It’s often referred to as a “mitochondrial signaler,” studied for its role in energy regulation, stress resistance, and insulin sensitivity.
Unlike many peptides that influence one specific system, MOTS-c appears to work upstream—impacting cellular energy pathways and helping the body adapt to metabolic stress.
What the Research Suggests
While research is still early and mostly preclinical, some exciting findings from studies include:
Potential support for insulin sensitivity and glucose regulation
Modulation of AMPK activation—a key energy sensor in the body
Studied for promoting mitochondrial biogenesis and energy efficiency
Investigated for exercise performance enhancement
Possible effects on fat metabolism and cellular protection during stress
In short, MOTS-c may help the body “act younger” at a cellular level, particularly under metabolic strain.
Current Availability
MOTS-c is not approved for clinical use and is primarily available for research purposes. As with all peptides, any consideration for personal use should involve a licensed provider familiar with experimental or investigational therapeutics.
Why It Matters
MOTS-c is part of a new class of “mitopeptides” being investigated for their ability to enhance resilience, longevity, and metabolic flexibility. It’s of high interest in anti-aging, athletic, and chronic health communities.
Want to Learn More?
InnerFlux exists to help you understand emerging peptide research like MOTS-c. If you’d like to discuss it with a provider, use the contact form to request a referral.
